Gabriel IglesiasPepe Rodriguez (voice)
Ana de la RegueraCarmen Sánchez (voice)
Dan NavarroChakal (voice)
Danny TrejoSkeleton Luis (voice)
Carlos AlazraquiGeneral Posada / Dali / Chuy (voice)
Emil-Bastien BouffardYoung Manolo (voice)
Elijah RodriguezYoung Joaquin
Genesis OchoaYoung Maria (voice)
Plácido DomingoSkeleton Jorge (voice)
Trey BumpassGoth Kid / Orphan
Ben GleibGoya / Dali (voice)
Ricardo El Mandril SanchezPablo Rodriguez (voice)
Ishan SharmaSanjay
Jorge R. GutierrezSkeleton Carmelo (voice)
Anjelah Johnson-ReyesAdelita / Nina (voice)
Kennedy PeilSasha (voice)
Sandra EquihuaScardelita (voice)
Callahan ClarkJane (voice)
Gunnar SizemoreIgnacio (voice)
Angélica MaríaSister Ana (voice)
Sandra EcheverríaClaudia (voice)
Tonita CastroLa Muerte as Old Woman (voice)
Guillermo del ToroLand of the Remembered Captain's Wife (voice)
Brad BookerConductor (voice)
Rosemary AlexanderAdditional Voices (voice)
Steve AltermanAdditional Voices (voice)
Eva BellaAdditional Voices (voice)
Madison CarlonAdditional Voices (voice)
Vicki DavisAdditional Voices (voice)
Moosie DrierAdditional Voices (voice)
Cullen McCarthyAdditional Voices (voice)
David MichieAdditional Voices (voice)
Michelle MooresAdditional Voices (voice)
Jonathan Nichols-NavarroAdditional Voices (voice)
Al RodrigoAdditional Voices (voice)
Marcelo TubertAdditional Voices (voice)
Lynnanne ZagerAdditional Voices (voice)
Ruth ZalduondoAdditional Voices (voice)
Newell AlexanderAdditional Voices (voice)
David CowgillAdditional Voices (voice)
Elisa GabrielliAdditional Voices (voice)
Richard MiroAdditional Voices (voice)
Arthur OrtizAdditional Voices (voice)
Nathaniel SemsenAdditional Voices (voice)
Joe MatthewsYoung Manolo (singer)
Jose AlvarezAdditional Voices (voice) (uncredited)
