Grey's Anatomy: Season 22

2025 · 18 episodes · ★ 8.1

What Season 22 of Grey's Anatomy

Season 22 kicks off with Grey Sloan trying to recover after a huge explosion has left the hospital in ruins. The doctors face the personal and professional fallout from that day, making impossible surgical decisions amid a lot of emotional confusion. A new generation of residents joins the rotations while the building remains under renovation. Conflicts unfold on several fronts: Teddy and Winston clash over a case, Owen and Jules treat difficult patients, and Richard struggles with his health. Meredith appears only occasionally, so the weight falls on the rest of the team.

18episodes

Oct 9, 2025aired

May 7, 2026latest episode

13.1 hrtotal runtime

Season 22 Episodes

22x01 Only the Strong Survive
Oct 9, 2025 · 43 min · ★ 8.4
After the catastrophic hospital explosion, Grey Sloan's staff scrambles to save not only their patients' lives but also their own. Confronted with impossible surgical decisions and emotional turmoil, they fight to preserve life amid devastation.
Directing: Debbie Allen · Writing: Meg Marinis · Starring: Debbie Allen, Natalie Morales, Branden Silverman, Floriana Lima
22x02 We Built This City
Oct 16, 2025 · 44 min · ★ 8.6
The team at Grey Sloan navigates a chaotic first day of surgical rotations amid hospital renovations. Meanwhile, Meredith spends time with Amelia.
Directing: Kevin McKidd · Writing: Zoanne Clack · Starring: Kelly McCreary, Frances Nichols, Kate Burton, Aniela Gumbs
22x03 Between Two Lungs
Oct 23, 2025 · 43 min · ★ 7.8
A high-risk lung transplant pushes the surgical team to their limits. Meanwhile, Bailey juggles a trauma patient whose treatment hangs in the balance.
Directing: Debbie Allen · Writing: Sandra Hamada · Starring: Scott Speedman, Rasta Thomas, Brody Goodstadt, Ryder Goodstadt
22x04 Goodbye Horses
Oct 30, 2025 · 43 min · ★ 7.7
The interns juggle a bizarre trauma, while a complex breast reconstruction forces Meredith into a tense partnership.
Directing: Sammi Cannold · Writing: Jase Miles-Perez · Starring: Jesse Williams, Frances Nichols, Floriana Lima, Sophia Bush
22x05 Sometimes I Feel Like a Motherless Child
Nov 6, 2025 · 44 min · ★ 8.4
Jo navigates a challenging case with a pregnant mother, while Blue and Jules care for a diabetic patient. Meanwhile, Simone treats a patient with a surprising revelation.
Directing: Bille Woodruff · Writing: Jess Righthand · Starring: Anton Starkman, Yadira Guevara-Prip, Ptosha Storey, Carolyn Kang
22x06 When I Crash Mid-Season Finale
Nov 13, 2025 · 44 min · ★ 8.4
Grey Sloan takes in patients following a catastrophic bus accident. Teddy and Owen have an awkward encounter, and Richard tests Bailey's patience.
Directing: Phylicia Rashād · Writing: Michelle Lirtzman · Starring: Jaicy Elliot, Rasta Thomas, Norman Nixon, Jr., Avalon Gray
22x07 Skyfall
Jan 8, 2026 · 44 min · ★ 8.0
Winston and Ben fight to save Jo's life, while Teddy supports Link. Owen and Jules battle to save a young man, and Lucas forms an unexpected bond with a patient.
Directing: Allison Liddi-Brown · Writing: Carol Brown · Starring: Jaicy Elliot, Branden Silverman, Samantha Marie Ware, Anita Kalathara
22x08 Heavy on Me
Jan 15, 2026 · 44 min · ★ 8.2
Bailey and Owen join forces to save a tumor patient, while Richard faces an internal battle. Meanwhile, Jules struggles with her feelings for Winston.
Directing: Lisa Leone · Writing: Tameson Duffy · Starring: Payton Silver, Debbie Allen, Melissa Oliver, Anton Starkman
22x09 Fortunate Son
Jan 22, 2026 · 43 min · ★ 8.7
Richard continues to navigate his health. Meanwhile, Meredith and Nick are visited by Nick's estranged sister from Boston.
Directing: Kim Raver · Writing: Julie Wong · Starring: Scott Speedman, Norman Nixon, Jr., Debbie Allen, JoAnna Rhambo
22x10 Strip That Down Mid-Season Finale
Jan 29, 2026 · 44 min · ★ 7.8
Addison Montgomery returns to Grey Sloan, seeking assistance with a patient with a neurological condition. Bailey joins Owen and Blue on a paramedic ride-along.
Directing: Kevin McKidd · Writing: Park Jin-Woo · Starring: Kate Walsh, Samantha Marie Ware, Anita Kalathara, Ben Levin
22x11 (If You Want It) Do It Yourself
Feb 26, 2026 · 45 min · ★ 8.0
Teddy and Winston clash over a case, while Owen and Jules treat a urologist. Lucas struggles with prioritizing patients.
Directing: Linda Klein · Writing: Scott D. Brown · Starring: Payton Silver, Debbie Allen, Gordon James, Kady Kepner
22x12 Get Lucky
Mar 5, 2026 · 44 min · ★ 8.0
Tensions rise as Teddy and Winston take on a complex procedure, while Kavita and Ben try and impress the new plastics attending. Jo and Link leave the babies with a nanny for the first time.
Directing: Chandra Wilson · Writing: Jess Righthand · Starring: Branden Silverman, Rasta Thomas, Norman Nixon, Jr., Karis Barry
22x13 Love the Way You Lie
Mar 12, 2026 · 44 min · ★ 8.0
Richard tackles a shocking case on his first day back, while Kavita and Jules prepare for a high-stakes presentation. Bailey must have a difficult conversation with a beloved patient, and Jo works to baby-proof the loft.
Directing: Allison Liddi-Brown · Writing: Sophia Arnao · Starring: Anton Starkman, Samantha Marie Ware, Anita Kalathara, Uyoata Udi
22x14 Wrecking Ball
Mar 19, 2026 · 43 min · ★ 8.0
A couple lands in the hospital with life-altering injuries after a wrecking ball destroys their home. Lucas and Simone struggle to support a young, terminally ill patient, and Richard hosts a prostate screening event.
Directing: Kevin McKidd · Writing: Michelle Lirtzman · Starring: Branden Silverman, Rasta Thomas, Gordon James, Jade Pettyjohn
22x15 Take Me to the River
Mar 26, 2026 · 43 min · ★ 8.0
Bailey and Blue are forced to confront the emotional costs of experimental care. Meanwhile, Owen, Teddy, Simone and Dani help out at a busy rural hospital, and Richard attempts to spread information about early prostate screenings to the community.
Directing: Bille Woodruff · Writing: Jase Miles-Perez · Starring: Frances Nichols, Jade Pettyjohn, Anton Starkman, Yadira Guevara-Prip
22x16 Feel It Still
Apr 2, 2026 · 44 min · ★ 8.0
Jo returns for her first full day back from leave, and Owen struggles to keep it together when someone close to him is admitted to Grey Sloan. Meanwhile, Bailey navigates hospital leadership.
Directing: Jake Borelli · Writing: Sandra Hamada · Starring: Jaicy Elliot, Branden Silverman, Debra Mooney, Avalon Gray
22x17 Through the Fire
Apr 30, 2026 · 43 min · ★ 7.9
A Station 19 firefighter lands in the ER for severe burn treatment, and the team treats an elderly patient impaled by an art structure. A Fox Foundation innovation competition reunites Meredith and Bailey.
Directing: Linda Klein · Writing: Julie Wong · Starring: Danielle Savre, Payton Silver, Frances Nichols, Gordon James
22x18 Bridge over Troubled Water Season Finale
May 7, 2026 · 43 min · ★ 7.6
After a catastrophic bridge collapse sends dozens of victims to Grey Sloan, the hospital activates its full disaster response as they race to treat a surge of critically injured patients, including one of their own.
Directing: Kevin McKidd · Writing: Meg Marinis · Starring: Scott Speedman, Payton Silver, Rasta Thomas, Norman Nixon, Jr.