Grey's Anatomy: Season 21

2024 · 18 episodes · ★ 8.2

What Season 21 of Grey's Anatomy

The season opens with the aftermath of the changes that shook Grey Sloan Memorial. After the firing of some of its best professionals, Catherine keeps interfering in the investigation that Meredith and Amelia are running, and tension builds throughout the hospital. Meredith clashes with Catherine and turns to Bailey for support. Teddy and Owen try to save their marriage, while Jo and Link prepare for their wedding. Lucas and Simone disagree about how to treat their patients, and Bailey continues to lead the training of the interns, where every decision carries weight.

18episodes

Sep 26, 2024premiered

May 15, 2025latest episode

13.1 hrtotal runtime

Season 21 Episodes

21x01 If Walls Could Talk
Sep 26, 2024 · 44 min · ★ 8.5
After firing some of Grey Sloan's best, Catherine continues to interfere with Meredith and Amelia's research. Accidents at a climate change protest bring unique cases to the hospital, and Bailey encounters a blast from the past.
Directing: Debbie Allen · Writing: Meg Marinis · Starring: Jesse Williams, Jake Borelli, Midori Francis, Kali Rocha
21x02 Take Me to Church
Oct 3, 2024 · 43 min · ★ 8.3
Meredith and Catherine continue to disagree, and Meredith confides in Bailey for support. Richard, Winston and Lucas spend the day outside of the hospital, and Blue deals with a relationship from his past. Levi meets the new hospital chaplain.
Directing: Kevin McKidd · Writing: Michelle Lirtzman · Starring: Jake Borelli, Midori Francis, Kali Rocha, Rasta Thomas
21x03 I Can See Clearly Now
Oct 10, 2024 · 43 min · ★ 9.0
Simone and Lucas work to balance their relationship while competing to assist on an awake kidney transplant. Teddy offers Amelia a new opportunity, and Ben's interview doesn't go as planned. Meredith's secret causes tension with Richard.
Directing: Victoria Mahoney · Writing: Mark Driscoll · Starring: Jake Borelli, Midori Francis, Scott Speedman, Kali Rocha
21x04 This One's for the Girls
Oct 17, 2024 · 44 min · ★ 8.7
Mika struggles with a life-altering personal matter. Meanwhile, Bailey and Ben navigate their personal and professional roles, while Levi finds a connection in an unlikely place. Jo and Link get surprising news.
Directing: Debbie Allen · Writing: Briana Belser · Starring: Jake Borelli, Midori Francis, Jaicy Elliot, Michael Thomas Grant
21x05 You Make My Heart Explode
Oct 24, 2024 · 44 min · ★ 8.3
During a high-stress day at Grey Sloan Memorial, the fates of a patient in critical condition and a helicopter-bound medical team hang in the balance. Teddy and Owen work on their marriage, while Bailey, Blue and Link treat a hospital employee.
Directing: Vanessa Parise · Writing: Zoanne Clack · Starring: Jake Borelli, Natalie Morales, JoAnna Rhambo, Michael Thomas Grant
21x06 Night Moves
Nov 7, 2024 · 44 min · ★ 7.1
Teddy and Owen plan a date night that gets derailed in more ways than one, while Jo struggles to do it all at home. Mika adds more to her plate to make up for taking time off to be with her sister, and Levi is faced with a monumental decision.
Directing: Bille Woodruff · Writing: Jase Miles-Perez · Starring: Jake Borelli, Midori Francis, Jaicy Elliot, Rasta Thomas
21x07 If You Leave
Nov 14, 2024 · 44 min · ★ 8.6
The doctors at Grey Sloan must put aside their emotions under intense circumstances. Levi asks James a shocking question that could impact their future.
Directing: Allison Liddi-Brown · Writing: Tameson Duffy · Starring: Jake Borelli, Midori Francis, Branden Silverman, Rasta Thomas
21x08 Drop It Like It's Hot Mid-Season Finale
Nov 21, 2024 · 44 min · ★ 7.8
In the midst of a deadly heat wave, the team at Grey Sloan struggles to keep up with an overwhelming amount of patients. Amelia and Winston face a challenging surgery, while Jo and Lucas run an errand for the hospital that takes an unexpected turn.
Directing: Kevin McKidd · Writing: Jess Righthand · Starring: Midori Francis, Rasta Thomas, Frances Nichols, Kevin Clarke
21x09 Hit the Floor
Mar 6, 2025 · 43 min · ★ 8.4
The aftermath of the convenience store shooting brings chaos to Grey Sloan. Ben hits a wall with his new emergency preparedness plan. Romantic tensions surface for Owen, while Amelia and Winston disagree over the surgical plan for a young patient.
Directing: Linda Klein · Writing: Jamie Denbo · Starring: Branden Silverman, Norman Nixon, Jr., Dianne Doan, Floriana Lima
21x10 Jump (For My Love)
Mar 13, 2025 · 43 min · ★ 7.1
Meredith and Nick return to Grey Sloan to treat a liver transplant patient. Meanwhile, Bailey hosts an intern retreat at her home, and Winston and Ben aid an unexpected crash victim.
Directing: Jesse Williams · Writing: Julie Wong · Starring: Scott Speedman, Jaicy Elliot, Debbie Allen, Matthew Case
21x11 I Still Haven't Found What I'm Looking For
Mar 20, 2025 · 44 min · ★ 7.3
Following a difficult case, the team faces the complexities of medical ethics. Meanwhile, Bailey continues to navigate her working relationship with Ben, while a group of college students on a scavenger hunt causes chaos around the hospital.
Directing: Kim Raver · Writing: Carol Brown · Starring: Scott Speedman, Norman Nixon, Jr., Frances Nichols, Debbie Allen
21x12 Ridin' Solo
Mar 27, 2025 · 44 min · ★ 8.3
Meredith and Amelia prepare a funding proposal for their Alzheimer’s research. Meanwhile, Teddy and Owen hit a breaking point in their marriage, while Jules has an awkward encounter with Dr. Beltran.
Directing: Morenike Joela Evans · Writing: Sandra Hamada · Starring: Scott Speedman, Greg Germann, Payton Silver, Aniela Gumbs
21x13 Don't You (Forget About Me)
Apr 3, 2025 · 44 min · ★ 7.2
Amelia and Simone attempt to perform a high-stakes and groundbreaking brain surgery. Teddy and Bailey attend a medical conference and run into Dr. Cass Beckman. Meanwhile, Jo struggles with her irritation toward a younger OB-GYN.
Directing: Kevin McKidd · Writing: Julie Wong, Michelle Lirtzman · Starring: Scott Speedman, Vince Swann, Dianne Doan, Floriana Lima
21x14 Love in the Ice Age
Apr 10, 2025 · 44 min · ★ 8.0
Bailey welcomes a renowned surgeon, whom she greatly admires, to Grey Sloan to help on a challenging case. Meanwhile, Teddy, Owen, Jules and Ben team up to save the life of a patient who has been impaled by an ice pick.
Directing: Morenike Joela Evans · Writing: Kingsley Ume · Starring: Rasta Thomas, Avalon Gray, Colette Gray, River Davidson
21x15 Bust Your Windows
Apr 17, 2025 · 43 min · ★ 8.4
A window washer’s platform crashes through a hospital window, testing the Grey Sloan team’s limits. Meanwhile, Blue and Simone clash over their living arrangements, and Lucas strives to impress Catherine while on her service.
Directing: Lisa Leone · Writing: Scott D. Brown · Starring: Jaicy Elliot, Branden Silverman, Debbie Allen, Gordon James
21x16 Papa Was a Rollin' Stone
May 1, 2025 · 44 min · ★ 9.1
Amelia undertakes a high-risk brain surgery on a young patient, while Winston and Jules disagree over how to handle their trauma patient's family. Jo and Link struggle with wedding planning.
Directing: Chandra Wilson · Writing: Jess Righthand · Starring: Jaicy Elliot, Laura Linda Bradley, Natalie Morales, Piper Perabo
21x17 Love You Like a Love Song
May 8, 2025 · 44 min · ★ 8.8
Jo and Link's wedding day arrives, along with some visitors. Meanwhile, Teddy and Owen are met with a familiar face seeking treatment, and Lucas disagrees with Simone on how to approach a patient's worsened condition.
Directing: Kevin McKidd · Writing: Julie Wong, Michelle Lirtzman · Starring: Trevor Jackson, Jake Borelli, Jaicy Elliot, Karis Barry
21x18 How Do I Live Season Finale
May 15, 2025 · 44 min · ★ 8.6
While the interns are excited to transition to second-year residency, an ordinary day at Grey Sloan takes an unexpected turn when a medical emergency unfolds in the operating room, endangering lives inside the hospital.
Directing: Debbie Allen · Writing: Meg Marinis · Starring: Trevor Jackson, Payton Silver, Frances Nichols, Debbie Allen