
Grey's Anatomy: Season 5
2008 · 24 episodes · ★ 8.3
What Season 5 of Grey's Anatomy
Season five opens with Meredith and Derek discovering that living happily ever after isn't as easy as it seemed. At Seattle Grace Hospital, the administration receives bad news: the hospital is no longer among the country's best teaching hospitals. Chief Webber decides to step up training, which complicates life for the entire staff. The residents must train their interns while advancing their own careers. Miranda Bailey remains the figure guiding the young surgeons, and Cristina, Izzie, Alex and George feel the pressure day by day. Romantic relationships and friendships suffer, especially between Meredith and Cristina, who clash while every decision weighs on the operating room.
Season 5 Episodes

5x01 Dream a Little Dream of Me (1)
As Meredith and Derek begin to find that their "happily ever after" is anything but easy, Cristina develops a crush on a military doctor who brings in a trauma patient. Meanwhile, the Chief and his staff cope with the news that Seattle Grace is no longer considered a top-tier teaching hospital.
Directed by: Rob Corn · Written by: Shonda Rhimes · Starring: Brooke Smith, Mark Saul, Cliff DeYoung, Lauren Stamile

5x02 Dream a Little Dream of Me (2)
Alex is offended when Izzie talks about how great a man Alex is to Meredith. Derek is stabbed with the scalpel in the palm of his hand by Rose, while the Chief is stunned over Mercy West's increase in the number of patients, a deadly ice storm ravages Seattle.
Directed by: Rob Corn · Written by: Shonda Rhimes · Starring: Brooke Smith, Mark Saul, Cliff DeYoung, Lauren Stamile

5x03 Here Comes the Flood
When the plumbing springs a leak, chaos breaks out at Seattle Grace as the Chief tries to put in place new teaching methods. Meanwhile, George takes his residency exam; and Derek attempts to get Meredith's roommates to move out, much to their surprise.
Directed by: Michael Pressman · Written by: Krista Vernoff · Starring: Brooke Smith, Gloria Garayua, Mark Saul, Kate Anthony

5x04 Brave New World
Meredith is sent into a state of panic when Derek finds her mother's diary in the house. Meanwhile, Callie stresses while preparing for her first date with Erica. Later, Cristina stumbles across a part of the hospital no one has ever seen before.
Directing: Eric Stoltz · Writing: Debora Cahn · Starring: Brooke Smith, Steven W. Bailey, Gloria Garayua, Mark Saul

5x05 There's No 'I' in Team
Bailey heads up a "domino procedure" in which each surgery hinges on the one preceding it. Meanwhile, Derek gets sole credit for the brain-tumor study he did with Meredith; Lexie tries to get George to notice her romantically; and Sloan counsels a desperate Callie in the ways of love.
Directed by: Randall Zisk · Written by: Jenna Bans · Starring: Brooke Smith, Steven W. Bailey, Gloria Garayua, Mark Saul

5x06 Life During Wartime
The chief gives Bailey new power and responsibility. He also gives her a very difficult surgical assignment: remove a girl's inoperable tumor. Meanwhile, new trauma chief Owen (Kevin McKidd) challenges the attendings' methods and the residents' skills.
Directing: James Frawley · Writing: Mark Wilding · Starring: Brooke Smith, Scott Haven, Gloria Garayua, Mark Saul

5x07 Rise Up
When the Chief makes an announcement that a solo surgery is up as an award, the residents are sent into a frenzy all trying to get an edge over one another. Meanwhile, Derek asks Bailey for advice after Cristina continues to interfere in his relationship with Meredith. Elsewhere, Erica uncovers a shocking connection between a resident and a patient.
Directing: Joanna Kerns · Writing: William Harper · Starring: Brooke Smith, Gloria Garayua, Mark Saul, Jeffrey Dean Morgan

5x08 These Ties That Bind
One of Meredith's oldest friends, Sadie, becomes an intern at Seattle Grace, but Mer's friends are less-than-welcoming to her.
Directed by: Eric Stoltz · Written by: Stacy McKee · Starring: Gloria Garayua, Mark Saul, August Schellenberg, Jeffrey Dean Morgan

5x09 In the Midnight Hour
Meredith, Cristina and Bailey come to Lexie and Sadie's rescue when a routine surgery goes horribly wrong, as Owen and Derek treat a man seriously injured while sleepwalking and Mark comforts the sleepwalker's distraught daughter.
Directing: Tom Verica · Writing: Joan Rater · Starring: Gloria Garayua, Mark Saul, Jeffrey Dean Morgan, Leslie Grossman

5x10 All by Myself Mid-Season Finale
Cristina is awarded the first solo surgery among the residents, but she is forced to give it up and choose her replacement; Lexie is impressed when Mark performs a cutting-edge procedure; Callie doesn't know if Sadie is friendly or flirtatious.
Directed by: Arlene Sanford · Written by: Peter Nowalk · Starring: Gloria Garayua, Mark Saul, Jeffrey Dean Morgan, Christa B. Allen

5x11 Wish You Were Here
Bailey teams with Seattle Grace's new pediatric surgeon, Dr. Arizona Robbins, to save the life of a young patient near and dear to her heart, as the admittance of a death row inmate at the hospital stirs anger in Derek and further erodes Meredith and Cristina's friendship; meanwhile, Callie and Sloan work as a team to fight their respective attractions to Sadie and Lexie, and Izzie tells Alex that she's seeing Denny.
Directed by: Rob Corn · Written by: Debora Cahn · Starring: Jessica Capshaw, Steven W. Bailey, Robin Pearson Rose, Gloria Garayua

5x12 Sympathy for the Devil
Derek's mother, Carolyn, makes a surprise visit to Seattle and meets Meredith for the first time, as Mark tries to conceal his relationship with Lexie from her as well; meanwhile, death row inmate William wishes to donate his organs to Bailey and Arizona's patient, as Owen and Cristina try to go on their first date.
Directing: Jeannot Szwarc · Writing: Jenna Bans · Starring: Jessica Capshaw, Gloria Garayua, Mark Saul, Candice Afia

5x13 Stairway to Heaven
Bailey grows desperate as a patient's condition becomes more and more dire. Everyone in the hospital is stepping up to try to find the boy a new organ donor, including Meredith, who considers a death row patient's wish to die before execution. Meanwhile, an injury leaves Mark in a compromising position in the OR and Cristina awkwardly avoids Owen.
Directing: Allison Liddi-Brown · Writing: Mark Wilding · Starring: Jessica Capshaw, Gloria Garayua, Moe Irvin, Mark Saul

5x14 Beat Your Heart Out
Now that Derek has the engagement ring, he searches for the perfect way to propose to Meredith, as Lexie demands that Mark go public with their relationship, and Bailey, encouraged by her work on recent cases and by Dr. Dixon, considers a new direction for her medical career.
Directed by: Julie Anne Robinson · Written by: William Harper · Starring: Jessica Capshaw, Mark Saul, Kate Anthony, Peter MacKenzie

5x15 Before and After
Addison, Naomi and Sam rush the ailing Archer to Seattle Grace and reunite with old friends Derek and Mark to help save his life; meanwhile, Izzie employs her fellow doctors in a medical game designed to help teach the interns, and Owen runs into a significant someone from his past
Directed by: Dan Attias · Written by: Joan Rater, Tony Phelan · Starring: Kate Walsh, Steven W. Bailey, Gloria Garayua, Mark Saul

5x16 An Honest Mistake
Derek's confidence is shaken like never before as he faces off with Addison over what course is best for their dying pregnant patient; Cristina calls the abilities of a renown surgeon into question after she botches a standard procedure; and Bailey, who has decided to pursue a fellowship in Pediatrics, is appalled by the Chief's less-than-stellar recommendation letter.
Directed by: Randall Zisk · Written by: Peter Nowalk · Starring: Jessica Capshaw, Kate Walsh, Gloria Garayua, Mark Saul

5x17 I Will Follow You Into the Dark
Derek decides to quit after learning that more of his patients have died than survived; Izzie's interns make an unsettling discovery about "Patient X."
Directing: Rob Corn · Writing: Jenna Bans · Starring: Jessica Capshaw, Loretta Devine, Gloria Garayua, Mark Saul

5x18 Stand By Me
After his fellow surgeons try and fail to bring Derek back to work, Meredith must summon the strength to convince him. Meanwhile the hospital is abuzz as Mark attempts a rare face transplant surgery. Cristina, at last awarded her first solo surgery, is more focused on the needs of her friends, and Izzie does her best to keep her medical condition a secret.
Directing: Jessica Yu · Writing: Zoanne Clack · Starring: Greta Sesheta, Mark Saul, Candice Afia, Larry Sullivan

5x19 Elevator Love Letter
All eyes are on Derek as he is set to perform his first surgery after his breakdown; attention is also set on Izzie, whose medical condition requires her to undergo a difficult surgery; and Owen has another PTSD episode that injures Cristina and traumatizes both of them, throwing the future of their relationship into question.
Directed by: Edward Ornelas · Written by: Stacy McKee · Starring: Jessica Capshaw, Gloria Garayua, Mark Saul, Candice Afia

5x20 Sweet Surrender
As she endures aggressive treatment for her cancer, Izzie throws herself into planning Derek and Meredith's wedding.
Starring: Jessica Capshaw, Mac Brandt, Héctor Elizondo, Moe Irvin

5x21 No Good at Saying Sorry (One More Chance)
As preparations continue for Meredith and Derek's wedding, Izzie receives a surprise hospital visit from her handful-of-a-mother, Robbie. Meanwhile, a newly sober Thatcher visits his daughters, Meredith and Lexie, in order to make amends, and the Chief and Meredith bitterly fight over a controversial medical case.
Directed by: Tom Verica · Written by: Krista Vernoff · Starring: Jessica Capshaw, Jeff Perry, Kellie Martin, Megan Henning

5x22 What a Difference a Day Makes
As Meredith, Derek and all of their friends prepare for the big wedding, a group of college students, injured in a car crash as they were heading to their graduation ceremony, is admitted to the ER. Meanwhile, Izzie fears the worst when she begins experiencing familiar symptoms.
Directed by: Rob Corn · Written by: Shonda Rhimes · Starring: Jessica Capshaw, Mac Brandt, Mark Saul, Candice Afia

5x23 Here's to Future Days
In the first part of the two hour season finale, Izzie spends time with a fellow cancer patient and contemplates whether or not to undergo a risky surgery, as Mark is ready to take his relationship with Lexie to the next level and a patient makes Owen reassess his place at Seattle Grace.
Directing: Bill D'Elia, Rob Corn · Writing: Debora Cahn, Allan Heinberg · Starring: Jessica Capshaw, Zach Gilford, Jeffrey Dean Morgan, Kimberly Elise

5x24 Now or Never Season Finale
In the second part of the two hour season finale, George delivers stunning news to Bailey, sending shockwaves throughout the hospital, and Izzie's friends anxiously await her recovery from surgery. Meanwhile Bailey is surprisingly displeased after being accepted into the pediatric fellowship program, and the victim of a near-fatal traffic accident brings the talents of Seattle Grace's doctors together. This is the second hour of a 2-hour season finale.
Directing: Bill D'Elia, Rob Corn · Writing: Debora Cahn, Allan Heinberg · Starring: Jessica Capshaw, Shannon Lucio, Brooke Blanchard, John Cappon
Season 5 Cast
Ellen PompeoMeredith Grey24 episodes
Chandra WilsonMiranda Bailey24 episodes
Kevin McKiddOwen Hunt24 episodes
Sara RamirezCallie Torres24 episodes
Mark SaulSteve19 episodes
Molly KidderIntern Megan17 episodes
Gloria GarayuaIntern Graciella15 episodes
Joe WilliamsonIntern Pierce13 episodes
Winston StoryIntern Leo13 episodes
Amrapali AmbegaokarIntern Dani13 episodes
Jessica CapshawArizona Robbins12 episodes
Candice AfiaIntern Laura12 episodes
Tymberlee HillIntern Claire10 episodes
Melissa GeorgeSadie Harris8 episodesAll Seasons
Season 12005 · 9 ep. · ★ 7.8
Season 22005 · 27 ep. · ★ 8.5
Season 32006 · 24 ep. · ★ 8.4
Season 42007 · 16 ep. · ★ 7.9
Season 62009 · 22 ep. · ★ 8.2
Season 72010 · 22 ep. · ★ 7.8
Season 82011 · 23 ep. · ★ 8.1
Season 92012 · 24 ep. · ★ 8.0
Season 102013 · 24 ep. · ★ 8.0
Season 112014 · 24 ep. · ★ 8.1
Season 122015 · 24 ep. · ★ 8.2
Season 132016 · 24 ep. · ★ 7.8
Season 142017 · 24 ep. · ★ 8.2
Season 152018 · 25 ep. · ★ 8.5
Season 162019 · 21 ep. · ★ 8.2
Season 172020 · 17 ep. · ★ 8.3
Season 182021 · 20 ep. · ★ 8.4
Season 192022 · 20 ep. · ★ 8.3
Season 202024 · 10 ep. · ★ 8.5
Season 212024 · 18 ep. · ★ 8.2
Season 222025 · 18 ep. · ★ 8.1
Season 232026 · 6 ep. · ★ 9.3Where to Watch Season 5 of Grey's Anatomy
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Frequently Asked Questions
How many episodes does Season 5 of Grey's Anatomy have?
Season 5 of Grey's Anatomy has 24 episodes.
When Did Season 5 of Grey's Anatomy Premiere?
Premiered on September 25, 2008.
Where to Watch Season 5 of Grey's Anatomy?
In Spain, on Disney Plus.
What is the best episode of Season 5?
According to TMDB user ratings, episode 5x24, "Now or Never", with 8.9.
































