
Common Side Effects
2025– · Animation, Sci-Fi & Fantasy, Comedy · 2 seasons · ★ 8.5
Synopsis of Common Side Effects
Marshall Cuso and Frances Applewhite are two old high school friends who reconnect when Marshall discovers the Blue Angel Mushroom, a fungus with healing effects that seems to cure any illness or injury. Frances is the more practical half of the duo, dealing with money problems and caring for her mother, while Marshall becomes obsessed with the mushroom's properties. Their search leads them to uncover a conspiracy involving Reutical Pharmaceuticals, one of the world's largest drug companies, and the government, which is determined to suppress any knowledge about the mushroom. The series is an adult animated show created by Joseph Bennett and Steve Hely, airing on Adult Swim, with voices by Dave King, Emily Pendergast and Mike Judge, among others.
2x01 · Episodio 1
January 24, 2027
Seasons of Common Side Effects
Cast by Common Side Effects
Dave KingMarshall Cuso (voice)11 episodes
Emily PendergastFrances Applewhite (voice)10 episodes
Mike JudgeRick Kruger (voice)10 episodes
Martha KellyAgent Harrington (voice)10 episodes
Joseph Lee AndersonAgent Copano (voice)10 episodes
Shannon WoodwardDiane (voice)8 episodes
Ben FeldmanNick (voice)8 episodes
Shalita GrantOncologist (voice)6 episodes
Christine KoKiki (voice)5 episodes
Alan ResnickZane (voice)3 episodes
Timothy SimonsTest Subject 3 (voice)3 episodes
Nicolas CantuTommy (voice)Episode 1Technical Details
- Created by
- Joseph Bennett, Steve Hely
- Address
- Camille Bozec, Sean Buckelew, Vincent Tsui
- Writing
- Steve Hely, Sophie Kriegel, Jon Foor, Emma Barrie, Jean Kyoung Frazier
- Music
- Nicolas Snyder
- Production
- Jonathan Roig, Paige Boudreaux, Jacey Bradley, Max Minor, Susan Shi
- Executive Producer
- Joseph Bennett, Mike Judge, Sean Buckelew, Suzanna Makkos
- Production companies
- Bandera Entertainment, Green Street Pictures, Williams Street, Tell Me More
- Network or Platform
- Adult Swim
- Country
- United States
- Original Language
- English
- Premiere
- February 2, 2025
- Latest episode aired
- March 30, 2025 (Season 1, Episode 10)
- Status
- Returning series
- Type
- Fiction
- Awards
- Nominated for 1 Emmy Awards; 4 wins and 10 nominations in total.
- Links
- IMDb · TMDB · Official Website
Trivia about Common Side Effects
Sources: Wikipedia (English)
Trailer for Common Side Effects

Where to Watch Common Side Effects
Subscription
More info and links
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Frequently Asked Questions
How many seasons does Common Side Effects have?
Common Side Effects has 2 seasons and 11 episodes in total, and it is still airing.
Where to watch Common Side Effects in Spain?
Common Side Effects is available on Movistar Plus+ Ficción Total, HBO Max and HBO Max Amazon Channel with a subscription.
When is the next episode of Common Side Effects coming out?
The next episode (2x01) premieres January 24, 2027.
Who's in Common Side Effects?
The main cast includes Dave King (Marshall Cuso (voice)), Emily Pendergast (Frances Applewhite (voice)), Mike Judge (Rick Kruger (voice)) and Martha Kelly (Agent Harrington (voice)).
Who created Common Side Effects?
Common Side Effects is a creation of Joseph Bennett and Steve Hely.
How long does it take to watch all of Common Side Effects?
With episodes of about 23 minutes, watching all 11 episodes takes approximately 4 hours.
Coming soonSeason 2Jan 24, 2027 · 1 ep.




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