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Common Side Effects

2025– · Animation, Sci-Fi & Fantasy, Comedy · 2 seasons · ★ 8.5

Returning seriesAdult Swim+16

Synopsis of Common Side Effects

Marshall Cuso and Frances Applewhite are two old high school friends who reconnect when Marshall discovers the Blue Angel Mushroom, a fungus with healing effects that seems to cure any illness or injury. Frances is the more practical half of the duo, dealing with money problems and caring for her mother, while Marshall becomes obsessed with the mushroom's properties. Their search leads them to uncover a conspiracy involving Reutical Pharmaceuticals, one of the world's largest drug companies, and the government, which is determined to suppress any knowledge about the mushroom. The series is an adult animated show created by Joseph Bennett and Steve Hely, airing on Adult Swim, with voices by Dave King, Emily Pendergast and Mike Judge, among others.

2seasons
11episodes
23 minper episode
8.5audience scoreTMDB · 363 votes
8.5IMDb rating22,354 votes
Next episode

2x01 · Episodio 1

January 24, 2027

Seasons of Common Side Effects

Cast by Common Side Effects

Dave KingDave KingMarshall Cuso (voice)11 episodes
Emily PendergastEmily PendergastFrances Applewhite (voice)10 episodes
Mike JudgeMike JudgeRick Kruger (voice)10 episodes
Martha KellyMartha KellyAgent Harrington (voice)10 episodes
Joseph Lee AndersonJoseph Lee AndersonAgent Copano (voice)10 episodes
Sue RoseHildy (voice)8 episodes
Shannon WoodwardShannon WoodwardDiane (voice)8 episodes
Ben FeldmanBen FeldmanNick (voice)8 episodes
Shalita GrantShalita GrantOncologist (voice)6 episodes
Steve HelyRusty (voice)6 episodes
Christine KoChristine KoKiki (voice)5 episodes
Alan ResnickAlan ResnickZane (voice)3 episodes
Timothy SimonsTimothy SimonsTest Subject 3 (voice)3 episodes
Jon FoorHoang (voice)3 episodes
Nicolas CantuNicolas CantuTommy (voice)Episode 1

Technical Details

Created by
Joseph Bennett, Steve Hely
Address
Camille Bozec, Sean Buckelew, Vincent Tsui
Writing
Steve Hely, Sophie Kriegel, Jon Foor, Emma Barrie, Jean Kyoung Frazier
Music
Nicolas Snyder
Production
Jonathan Roig, Paige Boudreaux, Jacey Bradley, Max Minor, Susan Shi
Executive Producer
Joseph Bennett, Mike Judge, Sean Buckelew, Suzanna Makkos
Production companies
Bandera Entertainment, Green Street Pictures, Williams Street, Tell Me More
Network or Platform
Adult Swim
Country
United States
Original Language
English
Premiere
February 2, 2025
Latest episode aired
March 30, 2025 (Season 1, Episode 10)
Status
Returning series
Type
Fiction
Awards
Nominated for 1 Emmy Awards; 4 wins and 10 nominations in total.
Links
IMDb · TMDB · Official Website

Trivia about Common Side Effects

Joe Bennett and Steve Hely met through Bandera Entertainment, the production company of Mike Judge and Greg Daniels, and discovered shared interests such as mushrooms, the pharmaceutical industry and South America.
Dave King was cast as Marshall after Bennett heard him on The Great Debates, a podcast he co-hosted with Steve Hely.
Adult Swim executives called Dave King "perfect" for the role, which put to rest the creators' doubts about his limited professional experience.
Amazon bought the project in 2019, but Steve Hely said the platform "didn't quite get it," so he ended up selling it to Warner Bros. Discovery.
The animation studio Green Street Pictures was founded in 2020 to create Scavengers Reign, and many of its artists later went on to work on this series.
The series was named among the best shows of 2025 by outlets such as The New York Times, The Hollywood Reporter, Los Angeles Times and The Guardian, and has a 100% approval rating on Rotten Tomatoes.
The first season received a nomination at the 2025 Primetime Emmy Awards in the Outstanding Animated Program category for the episode "Cliff's Edge."
Adult Swim renewed the series in March 2025 and announced that the second season will premiere on January 24, 2027, with streaming on HBO Max the following day.

Sources: Wikipedia (English)

Trailer for Common Side Effects

Common Side Effects trailer

Where to Watch Common Side Effects

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Cast of Common Side Effects in other movies and series

Top-Rated Episodes

  1. 1x03 Hildy ★ 7.9
  2. 1x10 Raid ★ 7.9
  3. 1x01 Pilot ★ 7.7
  4. 1x04 Dumpsite ★ 7.6
  5. 1x09 Cliff's Edge ★ 7.6

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Frequently Asked Questions

How many seasons does Common Side Effects have?

Common Side Effects has 2 seasons and 11 episodes in total, and it is still airing.

Where to watch Common Side Effects in Spain?

Common Side Effects is available on Movistar Plus+ Ficción Total, HBO Max and HBO Max Amazon Channel with a subscription.

When is the next episode of Common Side Effects coming out?

The next episode (2x01) premieres January 24, 2027.

Who's in Common Side Effects?

The main cast includes Dave King (Marshall Cuso (voice)), Emily Pendergast (Frances Applewhite (voice)), Mike Judge (Rick Kruger (voice)) and Martha Kelly (Agent Harrington (voice)).

Who created Common Side Effects?

Common Side Effects is a creation of Joseph Bennett and Steve Hely.

How long does it take to watch all of Common Side Effects?

With episodes of about 23 minutes, watching all 11 episodes takes approximately 4 hours.

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